杨凡力
博士，特聘研究员
工作及教育经历
2026.01-至今 成都大学，高等研究院，特聘研究员
2024.09-2025.11 四川大学华西医院，生物治疗研究中心，专职科研
2020.12-2024.04 四川大学华西医院，生物治疗研究中心，博士后
2017.09-2020.06 四川大学，生物治疗全国重点实验室，人类重大疾病生物治疗，医学博士
2016.10-2017.08 四川大学华西医院，助理实验师
2013.07-2016.09 普莱柯生物工程股份有限公司
2010.09-2013.06 吉林大学，动物医学学院，预防兽医学，农学硕士
2006.09-2010.06 西昌学院，动物科学学院，动物科学，农学学士
研究方向
1. 解析蛋白质结构，揭示病毒囊膜蛋白的结构特征及其在膜融合过程中构象变化的分子机制，致力于开发新型抗病毒策略
2. 运用基于机器学习的蛋白质设计工具，进行抗体亲和力提升、生物大分子Binder设计、小分子抑制剂筛选及鉴定
科研项目
1. 项目名称，国家自然科学基金面上项目，2026.01 – 2029.12，49万元，主持
2. 项目名称，国家自然科学基金青年科学基金项目（C类），2022.01 - 2024.12，30万，主持
3. 中国博士后科学基金特别资助（站前），2020.08 – 2023.08，18万，主持
4. 项目名称，成都大学人才引进启动项目，2026.01 – 2028.12，主持
学术任职
1. 担任《生物工程学报》青年编委
2. 担任《Emerging Microbes & Infections》、《hLife》、《Transboundary and Emerging Diseases》、《生物工程学报》、《微生物学通报》等杂志审稿人
代表性论文
1. Yang Fanli#, Lin Sheng#, Ye Fei#, Yang Jing#, Qi Jianxun#, Chen Zhujun, Lin Xi, Wang Jichao, Yue Dan, Cheng Yanwei, Chen Zimin, Chen Hua, You Yu, Zhang Zhonglin, Yang Yu, Yang Ming, Sun Honglu, Li Yuhua, Cao Yu, Yang Shengyong, Wei Yuquan, Gao George Fu*, Lu Guangwen*. Structural Analysis of Rabies Virus Glycoprotein Reveals pH-Dependent Conformational Changes and Interactions with a Neutralizing Antibody, Cell Host & Microbe, 2020, 27(3): 441-453. (IF=18.7/Top期刊)
2. Yang Jingyun#, Wang Wei#, Chen Zimin#, Lu Shuaiyao#, Yang Fanli#, Bi Zhenfei#, Bao Linlin#, Mo Fei, Li Xue, Huang Yong, Hong Weiqi, Yang Yun, Zhao Yuan, Ye Fei, Lin Sheng, Deng Wei, Chen Hua, Lei Hong, Zhang Ziqi, Luo Min, Gao Hong, Zheng Yue, Gong Yanqiu, Jiang Xiaohua, Xu Yanfeng, Lv Qi, Li Dan, Wang Manni, Li Fengdi, Wang Shunyi, Wang Guanpeng, Yu Pin, Qu Yajin, Yang Li, Deng Hongxin, Tong Aiping, Li Jiong, Wang Zhenling, Yang Jinliang, Shen Guobo, Zhao Zhiwei, Li Yuhua, Luo Jingwen, Liu Hongqi, Yu Wenhai, Yang Mengli, Xu Jingwen, Wang Junbin, Li Haiyan, Wang Haixuan, Kuang Dexuan, Lin Panpan, Hu Zhengtao, Guo Wei, Cheng Wei, He Yanlin, Song Xiangrong, Chen Chong, Xue Zhihong, Yao Shaohua, Chen Lu, Ma Xuelei, Chen Siyuan, Gou Maling, Huang Weijin, Wang Youchun, Fan Changfa, Tian Zhixin, Shi Ming, Wang Fu-Sheng, Dai Lunzhi, Wu Min, Li Gen, Wang Guangyu, Peng Yong, Qian Zhiyong, Huang Canhua, Lau Johnson Yiu-Nam, Yang Zhenglin, Wei Yuquan, Cen Xiaobo, Peng Xiaozhong, Qin Chuan, Zhang Kang*, Lu Guangwen*, Wei, Xiawei*. A vaccine targeting the RBD of the S protein of SARS-CoV-2 induces protective immunity, Nature, 2020, 586(7830): 572-577. (IF=48.5/ESI高被引论文/Top期刊)
3. Yang Fanli, Lin Sheng, Yuan Xin, Shu Siqi, Yu Yueru, Yang Jing, Ye Fei, Chen Zimin, He Bin, Li Jian, Zhao Qi, Ye Haoyu, Cao Yu, Lu Guangwen*. Structures of two lyssavirus glycoproteins trapped in pre- and post-fusion states and the implications on the spatial-temporal conformational transition along with pH-decrease. PLOS Pathogens, 2025, 21(2): e1012923. (IF=4.9/Top期刊)
4. Yang Fanli#*, Zhai Lili#, Yin Keqing#, Lin Sheng, Yang Jing, Ye Fei, Chen Zimin, Shu Siqi, Yu Yueru, Guo Liyan, He Bin, Wang Wei, Ye Haoyu, Cao Yu, Gao Jian*, Lu Guangwen*. Molecular basis of two broad-spectrum antibodies neutralizing rabies virus and other phylogroup-I lyssaviruses by blocking structural transition between the pleckstrin-homology and fusion domains in the glycoprotein. International Journal of Biological Macromolecules, 2025, 308:142570. (IF=8.5/Top期刊)
5. Yang Fanli#, Lin Sheng#, Chen Zimin, Yue Dan, Yang Ming, He Bin, Cao Yu, Dong Haohao; Li Jian; Zhao Qi; Lu Guangwen*. Structural basis of poxvirus A16/G9 binding for sub-complex formation. Emerging Microbes & Infections, 2023,12 (1): 217935. (IF=7.5/Top期刊)
6. Ye Fei#, Yang Fanli#, Yu Ruijie, Lin Xi, Qi Jianxun, Chen Zhujun, Cao Yu, Wei Yuquan, Gao George Fu, Lu Guangwen*. Molecular basis of binding between the global posttranscriptional regulator CsrA and the T3SS chaperone CesT, Nature Communications, 2018, 9(1):1196. (IF=15.7/Top期刊)
7. Li Xiangdong#, Yang Fanli#, Hu Xule#, Tan Feifei, Qi Jianxun, Peng Ruchao, Wang Min, Chai Yan, Hao Liying, Deng Junhua, Bai Chenyu, Wang Juan, Song Hao, Tang Shuguang, Lu Guangwen, Gao George Fu; Shi, Yi*; Tian Kegong*. Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design. PLOS Pathogens, 2017, 13(12): e1006777. (IF=4.9/Top期刊)
8. He Biao#, Yang Fanli#, Yang Weihong#, Zhang Yuzhen, Feng Yun, Zhou Jihua, Xie Jinxin, Feng Ye, Bao Xiaolei, Guo Huancheng, Li Yingying, Xia Lele, Li Nan, Matthijnssens Jelle, Zhang Hailin*, Tu Changchun*. Characterization of a novel G3P[3] rotavirus isolated from a lesser horseshoe bat: a distant relative of feline/canine rotaviruses. Journal of Virology, 2013, 87(22): 12357-12366. (IF=3.9/中科院二区)
