龚艳秋
博士，特聘研究员
工作及教育经历
2025.12-至今 成都大学，高等研究院，特聘研究员
2021.11-2025.9 四川大学华西医院，博士后
2018.09-2021.6 四川大学，生物治疗全国重点实验室，生物化学与分子生物学，理学博士
2015.09-2018.06 四川大学，生物治疗全国重点实验室，生物化学与分子生物学，理学硕士
2011.09-2015.06 南昌大学，药学院，药学，理学学士
研究方向
1. 抗耐药菌组学研究
2. 基于高分辨质谱的蛋白质组学和修饰组学技术开发及应用
科研项目
1. 基于时空分辨率的磷酸化蛋白质组学系统揭示大肠衰老关键磷酸化通路的功能和机制，国家自然科学青年基金项目，2023.01 - 2025.12，30万，主持
2. 阿司匹林通过赖氨酸水杨酰化调控ALDOA活性和糖酵解的新机制研究，中国博士后基金面上项目，2024.01 - 2024.12，8万，主持
3. 基于时空分辨率的食蟹猴肠道磷酸化蛋白质组学系统揭示大肠衰老关键磷酸化位点的功能和机制研究，四川省科技厅自然科学基金青年项目，2023.01 - 2024.12，10万，主持
4. 鉴定赖氨酸水杨酰化是阿司匹林调节ALDOA活性和糖酵解的一种新机制，四川大学华西医院研发基金，2023.01 - 2024.12，15万，主持
5. 抗耐药菌组学研究，成都大学人才引进启动项目，2025.12 – 2028.11，100万，主持
代表性论文
1. Yanqiu Gong#, Huiwen Zhan#, Ni Wei#, Min Liu#, Yu Liu#, Pengbo Guan, Yusi Xie, Yujun Deng, Qianlun Pu, Xiaoxian Lou, Xiaodong Wang, Rou Zhang, Ping Wang, Xiuxiu Jin, Xiuxuan Wang, Zhiqiang Xu, Li Gao, Xinyuan Wang, Siyu He, Ying Lu, Meng Hu, Wanmeng Li, Kun Zheng, Yong Peng, Peng Lei, Heng Xu, Yujun Shi, Jun Qin, Hongbo Hu*, Huiyuan Zhang*, Lunzhi Dai*. Acetylation profiling by Iseq-Kac reveals insights into HSC aging and lineage decision. Nat Chem Biol. 2025, 21(11):1675-1687. (IF=13.7 / Top期刊)
2. Yanqiu Gong#, Suideng Qin#, Lunzhi Dai*, Zhixin Tian*. The glycosylation in SARS-CoV-2 and its receptor ACE2. Signal Transduct Target Ther. 2021, 6(1):396. (IF=52.7 / Top期刊)
3. Xinyuan Wang#, Yaru Luo#, Siyu He#, Ying Lu#, Yanqiu Gong#, Li Gao, Shengqiang Mao, Xiaohui Liu, Na Jiang, Qianlun Pu, Dan Du, Yang Shu, Shan Hai, Shuangqing Li, Hai-Ning Chen, Yi Zhao, Dan Xie, Shiqian Qi, Peng Lei, Hongbo Hu, Heng Xu, Zong-Guang Zhou, Biao Dong*, Huiyuan Zhang*, Yan Zhang*, Lunzhi Dai*. Age-, sex- and proximal-distal-resolved multi-omics identifies regulators of intestinal aging in non-human primates. Nat Aging. 2024, 4(3):414-433. (IF=19.4 / Top期刊)
4. Meng Hu#, Chenxi Zhu#, Rui Sun#, Zhiqiang Xu#, Yanqiu Gong#, Yi Liu#, et al. Low-input citrullinomics and deep learning reveal insights into rheumatoid arthritis onset, treatment response and autoantigens. Nat Biomed Eng. 2025, Accepted. (IF=26.6 / Top期刊)
5. Yanqiu Gong#, Yu Liu#, Tian Wang#, Zhigui Li#, Li Gao, Haining Chen, Yang Shu, Yuan Li, Heng Xu, Zongguang Zhou*, Lunzhi Dai*. Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Mol Cell Proteomics. 2021:20:100115. (IF=5.5 / Top期刊)
6. Yuling Li#, Yanqiu Gong#, Yue Zhou#, Yuzhou Xiao, Wenxin Huang, Qiao Zhou, Yingfeng Tu, Yinglan Zhao, Shuyu Zhang*, Lunzhi Dai*, Qingxiang Sun*. STK19 is a DNA/RNA-binding protein critical for DNA damage repair and cell proliferation. J Cell Biol. 2024;223(2):e202301090. (IF=6.4 / Top期刊)
7. Yue Ming#, Yanqiu Gong#, Xuewen Fu, Xinyu Ouyang , Yong Peng*, Wenchen Pu*. Small-molecule-based targeted therapy in liver cancer. Mol Ther. 2024;32(10):3260-3287. (IF=12.0 / Top期刊)
8. Yanqiu Gong#, Lunzhi Dai*. Decoding Ubiquitin Modifications by Mass Spectrometry. Adv Exp Med Biol. 2024:1466:1-18.
9. Yanqiu Gong#, Litong Nie, Lunzhi Dai*. Beyond proteins: Ubiquitylation of lipopolysaccharide to fight bacteria. MedComm. 2021, 2(4): 855-857. (IF=10.7)
10. Yuping Tan#, Xia Zhou#, Yanqiu Gong#, et al. Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors. Cell Mol Life Sci. 2022, 79(1): 27. (IF= 6.2/ Top期刊)
11. Yanqiu Gong#, Wenchen Pu, et al. Quantitative proteomics of CSF reveals potential predicted biomarkers for extranodal NK-/T-cell lymphoma of nasal-type with ethmoidal sinus metastasis. Life Sci. 2018, 1:198:94-98. (IF = 8.0)
